Turky Saad AlGraene
College of Medicine, Prince Sattam Bin Abdulaziz University, Al-Kharj, KSAPublications
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Research
Colorectal Cancer Diagnosis by detection of MicroRNA-92 in the Serum
Author(s): Ali Hassan A Ali*, Mohammed H Karrar Alsharif, Mohammed Mobarak M Almudarra, Turky Saad AlGraene, Moataz Daadour, Yousef M Alsomali, Mohammed Abdullah Aldossari and Ahmed M Alsomali
Colorectal cancer is the third most prevalent tumor worldwide, with a median age of 53 years and a predominance in men. We desperately require a gold standard for early detection and non-invasive diagnosis. Micro RNA 92a, a novel tumor marker, was shown to be highly concentrated in the serum of colorectal cancer patients. The present study aimed to assess the miR-92a expression level as a stable blood-based biomarker for the detection of colorectal cancer. This prospective observational study was carried out on 65 subjects. The cases group comprised 44 consecutive naive patients with colorectal cancer proved by colonoscopy and histopathological examination of biopsied specimens. Twenty-one subjects without colorectal cancer and normal colonoscopy served as the control group. Quantitative real-time RT-PCR was applied to determine the relative expression level of miRNA-92a in serum. Acc.. Read More»