Selvaraj Jayaraman
Department of Biochemistry, Saveetha Dental College & Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, IndiaPublications
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Research
Estimation of Clinocopathological Correlation and Comparison of Salivary TNF-? among Normal and Post Radiotherapy Patients of Oral cancer-A Cross-Sectional Study
Author(s): Akifa Begum, Palati Sinduja*, R Priyadharshini and Selvaraj Jayaraman
Introduction: Tumour Necrosis Factor-Alpha (TNF-α) is a member of the TNF receptor (TNF/TNFR) cytokine family. TNF-α is mainly involved in the maintenance of the source and homeostasis of the basic immune system, inflammation, and host defence. TNF- α is a multifunctional cytokine that plays an important role in diverse and a variety of cellular events such as cell survival, proliferation, differentiation, and death. As a major proinflammatory cytokine, TNF-α can act as an endogenous tumor promoter to bridge inflammation and carcinogenesis. Aim: The aim of the present study is to evaluate the efficacy of TNF- α as a salivary biomarker in oral cancer. Materials and Methods: An invivo cross-sectional study was conducted on saliva samples of Well differentiated and Moderately differentiated Squamous Cell Carcinoma (WDSCC and MDSCC) patients. Unstimulated sal.. Read More»