Satish Kumar Gupta
Department of Ophthalmology, Government Medical College, Jammu, Jammu and Kashmir, IndiaPublications
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Research
A Comparative Study of Efficacy and Safety of Topical Loteprednol Etabonate 0.5% and Cyclosporin A 0.05% for the Treatment of Vernal Keratoconjunctivitis
Author(s): Sharika Ganjoo, Sachit Mahajan*, Sanjay Kai and Satish Kumar Gupta
Background: Vernal keratoconjunctivitis (VKC) is a recurrent, bilateral, interstitial, allergic seasonal conjunctivitis. Topical steroids are one of the most effective drugs for management of signs and symptoms of VKC. Cysclosporin is a calcineurin inhibitor that abolishes T cell proliferation, decreasing histamine release from mast cells and basophils. This study was conceptualized to evaluate the safety and efficacy of loteprednol etabonate 0.5% and cyclosprin-A 0.05% to generate evidence for managing VKC more effectively. Material and methods: This non blinded comparative study included 200 patients with mild to moderate VKC who were randomized to two groups A and B. Group A received topical loteprednol etabonate 0.5% four times a day and group B received topical cyclosporin-A 0.05% two times a day. Five symptoms and four signs were evalu.. Read More»