Sapna Sharma
Department of Obstetrics and Gynaecology, Jawaharlal Nehru Medical College, DattaMeghe Institute of Medical Sciences (Deemed to be University), Sawangi (Meghe), Wardha, Maharashtra, IndiaPublications
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Research
Insulin Resistance and Its Associations
Author(s): Utkarsh Shrivastava, Anika Dahiya*, Sapna Sharma and Akshay Dahiwele
Insulin resistance occurs when a given amount of artificial or natural (endogenous) insulin fails to make the cell absorb and utilize the glucose as same level as it does in the general population (Normal level of insulin in our bodies is about 5-15ul/ml of blood) .insulin acts by binding to a particular receptor present on the plasma membrane of target tissue. Which is subsequently transported into the cell via a sequence of protein-protein interactions. Intracellular insulin action is mediated by two primary protein-protein interaction cascades: one is related to regulate intermediate metabolism, and the other is involved in controlling the process of growth as well as mitosis of cell. It is possible to separate the regulation of these two different pathways. Indeed, some evidence suggests that in type 2 diabetes, the system governing intermediate metabolism is impaired, but the pat.. Read More»