Mohammad Shokrzadeh
Department of Toxicology, Mazandaran University of medical sciences, Sari, IranPublications
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Research Article
The Effects of Valproic Acid on Cell Viability of Breast Cancer and Genotoxicity of Human Lymphocytes Blood Cell Line
Author(s): Mohammad Shokrzadeh*, Mona Modanloo, Sara Samadi, Imge kunter and Hosna Haghighi
Introduction Breast cancer is a complicated and multifactor disease in which so many genetic and environment agents play important roles. Nowadays different ways are available for cancer therapy such as surgery, chemotherapy and radiotherapy that are very costly and have various side effects. Valproic acid is an inhibitor of histone deacetylase enzyme that is effective on apoptosis of some cancerous cells. Aim The aim of this research is to evaluate the toxic effects of this drug on both normal and cancerous cells, alongside with causing genetic disorder on peripheral blood lymphocytes as a model to evaluate genetic disorder. Material and methods Cells were incubated with different concentrations of valproic acid and cisplatin. This incubation lead to cytotoxicity and Geno toxicity and then the .. Read More»