Ghufran Mohammed SS Al-Ali
Department of Pediatric and Preventive Dentistry, College of Dentistry, University of Baghdad, IraqPublications
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Research
The Relation of Salivary Cathelicidin and Beta-Defensin with Dental Caries of Schoolchildren
Author(s): Ghufran Mohammed SS Al-Ali*, Zainab Juma Jafar and Batool Hasan AL-Ghurab
Background: Salivary antimicrobial peptides contribute to oral health by playing a role in innate response against oral diseases, owing to their antimicrobial, antiplaque and immunomodulatory activity. Aim of study: This study was performed to determine the levels of cathelicidin LL-37 and beta-defensins in saliva of children, and assess the relationship of both biomarkers to dental caries prevalence and severity. Materials and Methods: Eighty-eight schoolchildren of age 6-7 years participated in the study. The sample was divided into two groups; study group of 44 children with moderate/severe caries and control group of 44 children free from caries. Oral examination and measurement of clinical parameters of caries experience by dmf index, caries severity by ICDAS index. Saliva samples were collected from both groups, then submitted to enzyme-linked immunosorbent assay. Results: A non.. Read More»