Fakunle PB
Department of Anatomy, Olabisi Onabanjo University, NigeriaPublications
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Research Article
Assessment of the Ameliorative Effects of Aqueous Neem (Azadirachta Indica) Leaves Extract on Lead Acetate Induced Neurotoxicity in Cerebellum of Adult Wistar Rats
Author(s): Fakunle PB, Ehiremen Samuel*, Atata Roy, Omotosho DA and Taiwo-Ola DO
Lead is a heavy metal that can cause oxidative stress, inflammation, and neuronal damage in the central nervous system, especially in the cerebellum, which is responsible for motor coordination and cognitive function. Neem plant also called Azadirachta Indica is a medicinal plant that has antioxidant, anti-inflammatory, and neuroprotective properties according to previous literatures. This study aim to assess the ameliorative effect of aqueous neem leaf extract (Azadirachta Indica) on lead acetate induced neurotoxicity in cerebellum of adult wistar rat evaluating body weight, Histology, Lactate Dehydrogenase level, Catalase (CAT) and Super-Oxide Dismutase (SOD) parameter. After a period of 14 days of acclimatization, 20 adult wistar rats weighing(150-200g) were randomly allocated to four groups, group1(distilled water only), group2 Lead only(70mg/kgPO), group3 A. Indica extract (200mg.. Read More»