Ehiremen Samuel

Department of Anatomy, Ladoke Akintola University of Technology Ogbomoso Oyo State, Nigeria, Nigeria

Publications

  • Research Article   
    Assessment of the Ameliorative Effects of Aqueous Neem (Azadirachta Indica) Leaves Extract on Lead Acetate Induced Neurotoxicity in Cerebellum of Adult Wistar Rats
    Author(s): Ehiremen Samuel*

    Lead is a heavy metal that can cause oxidative stress, inflammation, and neuronal damage in the central nervous system, especially in the cerebellum, which is responsible for motor coordination and cognitive function. Neem plant also called Azadirachta Indica is a medicinal plant that has antioxidant, anti-inflammatory, and neuroprotective properties according to previous literatures. This study aim to assess the ameliorative effect of aqueous neem leaf extract (Azadirachta Indica) on lead acetate induced neurotoxicity in cerebellum of adult wistar rat evaluating body weight, Histology, Lactate Dehydrogenase level, Catalase (CAT) and Super-Oxide Dismutase (SOD) parameter. After a period of 14 days of acclimatization, 20 adult wistar rats weighing(150-200g) were randomly allocated to four groups, group1(distilled water only), group2 Lead only(70mg/kgPO), group3 A. Indica extract (200mg.. Read More»

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