Comparative Study of Costus Igneus and Metformin in In-Vitro Inhibitory Activity of α-Amylase and α-Glucosidase Activity
Author(s): Sanjana V, Tanuja Lella*, Arul Amutha Elizabeth, Roshni AS, Brigida S and Vishnupriya G
Abstract
The objective of the present study was to compare the α-amylase and α-glucosidase inhibition activity of aqueous extracts of costus igneus with that of metformin in in-vitro studies. Different concentrations of the aqueous extract of the leaf from the plant costus igneus and the solution of drug metformin (100-500 μl) and standard drug (Acarbose) were taken and assessed for the antidibetic activity based on their α-amylase and α-glucosidase inhibition.
The alpha-amylase inhibition action of Costus igneus was 89% of that of metformin at a concentration of 500 μg. The alpha-glucosidase inhibition action of Costus igneus was 66.6% of that of metformin at a concentration of 500 μg. The study has shown good results and could be a potential topic for exploration of antidiabetic properties. The aqueous extract of the leaves of Costus igneus could serve as an alternative to the commonly used antidiabetic drug metformin. However further studies need to be performed to assess its safety profile.