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The Gas Chromatography Mass Spectroscopy Analysis of One Unani Drug, "Majoon Dabeedulward"

Journal of Research in Medical and Dental Science
eISSN No. 2347-2367 pISSN No. 2347-2545

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Research Article - (2022) Volume 10, Issue 8

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The Gas Chromatography Mass Spectroscopy Analysis of One Unani Drug, "Majoon Dabeedulward"

Hassan mohammad M1, Janaki CS2, Rao MRK3*, Prabhu K4, Deepa K5, Franklin6 and Vijayalakshmi N7

*Correspondence: Rao MRK, Department of Anatomy, Amritha University, Thiruporur, Tamil Nadu, India, Email:

Author info »

Abstract

The Unani Drug, “Majoon Dabeedulward” is prescribed for digestive and liver ailments. The drug was bought from a Unani medicine supplier and was processed suitably for gas chromatography mass spectroscopic analysis. The profile showed metabolites, namely, Propanoic acid, 2,2-dimethyl-, 2-ethylhexyl ester, trans-2-methyl-4-n-pentylthiane, S,S-dioxide, Eugenol, alpha-Santalol, Benzoic acid, 3-hydroxy- etc. which have a wise ranges of medicinal properties.

Keywords

GC MS, Unani Medicine, Majoon dabeedulward, Eugenol, Alpha-Santalol, Benzoic acid, 3-Hydroxy

Introduction

Majoon Dabeedulward is one herbal Unani medicine used to treat digestive and liver ailments. The main ingredients are mentioned below:

Izkhar Makki (Cymbopogon jwarancusa), Agar Hindi (Aquliaria agallocha), Balchhar (Nardosachys jatamansi), Banslochan (Bambusa arundinacea Retz.), Tukhm Kansi (Cichorium intybus), Tukhm Kassos (Cuscuta reflexa), Tukhm karafs (Apium graveolens) and Taj Qalmi (Cinnamomum cassia).

Very few reports are available on the scientific work for this medicine. Shakya et al. have evaluated the hepato-protective role of this drug [1]. Khan and Khan have reported the effects of this drug on fibroids [2]. Bozorgi, 2017 have reported the antioxidant role of this drug [3]. The description of this medicine finds its reference in Pharmacopoea Commission of Indian Medicines and Homoepathy, 2004 [4]. The present workers have worked to scientifically evaluate the veracity of these medicine systems by latest techniques so that deeper knowledge of the mechanism of action of these medicines could be gained [5-23]. The present study in one step further in this endeavour.

Materials and Methods

Majoon Dabeedulwardwas bought from a Unani medicine vendor in Chennai. The medicine was suitably processed by standard procedures and the GC-MS analysis was performed.

Results

The gas chromatography mass spectroscopic profile of Majoon Dabeedulward and possible medicinal role of each metabolite is tabulated in Table 1.

Ret. Time Molecule Mol. Formula Mol. Mass % Peak Area Possible Medicinal Role
3.69 Decane, 2,8,8-trimethyl- C13H28 184.2 1.60 Not known
3.75 Propanoic acid, 2,2-dimethyl-, 2-ethylhexyl ester C13H26O2 214.2 2.50 Arachidonic acid inhibitor
4.55 trans-2-methyl-4-n-pentylthiane, S,S-dioxide C11H22O2S 218.1 10.11 Glutathione S Transferase inhibitor, catechol O methyl transferase inhibitor, Myo neuro stimulant, Nitric oxide synthatase inhibitor, NO scavenger, Stimulates norepinephrine production, stm=ulated Sympathetic nervous sytem, decreases glutamate oxaloacetate transaminase, decreases glutamate pyruvate transaminase, glycosyl transferase inhibitor, reverse transcriptase inhibitor, transdermal, smart drug, adrenal stimulator
7.53 Phenol, 2,4-bis(1,1-dimethylethyl)- C14H22O 206.2 7.51 Not known
8.06 Methylparaben C8H8O3 152 9.76 Not known
8.88 .alpha.-Santalol C15H24O 220.2 1.65 5 alpha reductase inhibitor, alpha agonist, alpha amylase inhibitor, alpha glucosidase inhibitor, alpha reductase inhibitor, HIF 1 alpha inhibitor, Ikappa B alpha phosphorylation inhibitor, increases alpha mannosidae activity, Interleukine 1 alpha inhibitor, testosterone 5 alpha reductase inhibitor, TNF alpha inhibitor
9.29 Propylparaben C10H12O3 180.1 4.22 Not known
9.32 Isobutyl 4-hydroxybenzoate C11H14O3 194.1 3.95 Not known
9.39 Benzoic acid, 3-hydroxy- C7H6O3 138 1.99 17 beta hydroxyl-steroid dehydrogenase inhibitor, aryl hydrocarbon hydroxylase inhibitor, testosterone hydroxylase inducer, catechol-o-methyl transferase inhibitor

Table 1: Indicates the retentions values, types of possible compound, their molecular formulae, molecular mass, peak area and their medicinal roles of each compound as shown in the GC MS profile of Majoon Dabeedulward.

Figure 1 shows the gas chromatography mass spectroscopic profile the Unani medicine Majoon Dabeedulward. The identification of metabolites was done by comaoring with NIST spectral library and the possible pharmaceutical roles of each bio molecule as per National Agriculture Library, USA and others as shown in Table 1 [24].

medical-denta-science

Figure 1: indicates the GC MS profile of Majoon Dabeedulward.

Discussion

The Gas chromatography mass spectroscopic of Majoon Dabeedulward showed compounds namely, Propanoic acid, 2,2-dimethyl-, 2-ethylhexyl ester, trans-2-methyl-4-n-pentylthiane, S,S-dioxide, Eugenol, alpha-Santalol, Benzoic acid, 3-hydroxy- etc. which have a wide ranges of medicinal properties. These molecules contribute to the medicinal role of Majoon Dabeedulward.

Conclusion

It could be summarized from the results and discussion that Khushta Hajrul Yahood does contain important biomolecules which provides a clue to its prescription for the urolithiatic role of this medicine. It will be of interest to probe into the medicinal roles of many compound present in Khushta Hajrul Yahood for which the medicinal roles are not reported yet.

References

Author Info

Hassan mohammad M1, Janaki CS2, Rao MRK3*, Prabhu K4, Deepa K5, Franklin6 and Vijayalakshmi N7

1Department of Anatomy, Northern Borders University, Arar, Saudi Arabia
2Department of Anatomy, Bhaarath Medical College, Chennai, Tamilnadu, India
3Department of Anatomy, Amritha University, Thiruporur, Tamil Nadu, India
4Department of Anatomy, Sree Balaji Medical College and Hospital, Chennai, Tamil Nadu, India
5Department of Anatomy, Quest International University, IPOH Perak, Malaysia
6Dept of Microbiology, CEO Anna Medical College, Mauritius, Montagne Blanche, Island, Mauritania
7Department of Chemical and Biotechnology, SASTRA (Deemed to be University), Thanjavur, Tamil Nadu, India
 

Citation: Hassan mohammad M, Janaki CS, Rao MRK, Prabhu k, deepa k, Franklin, Vijayalakshmi N, The Gas Chromatography Mass Spectroscopy Analysis of One Unani Drug, “Majoon Dabeedulward”, J Res Med Dent Sci, 2022, 10 (8): 000-000.

Received: 09-Jun-2022, Manuscript No. JRMDS-22-57363; , Pre QC No. JRMDS-22-57363; Editor assigned: 11-Jun-2022, Pre QC No. JRMDS-22-57363; Reviewed: 25-Jun-2022, QC No. JRMDS-22-57363; Revised: 12-Aug-2022, Manuscript No. JRMDS-22-57363; Published: 24-Aug-2022

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