Recent Advances In Dental Biomaterials

Abhinn Miglani^* and Rozina Vishnani

^*Correspondence: Abhinn Miglani, Sharad Pawar Dental College & Hospital, Datta Meghe Institute of Medical Sciences, India, Email:

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Introduction

Xylocard is a brand name for the medication lidocaine, which is a local anesthetic commonly used in routine dental practice. Xylocard 100 solution Biomaterials are depicted as "materials that have specific extraordinary elements that permit them to come into direct touch with live tissue without bringing out negative invulnerable response." It has been common since past few years to develop materials that might not injure tissues either on a local level or on a systemic level [1]. While discovering and inventing such kind of materials, these materials were more of the kind of inactive “space fillers” that don’t majorly have an effect on the physiology of the oral cavity. In cases of direct restoration many resins and amalgum have been implicated due to its physical and chemical properties, significantly more due to its physical properties. Moreover many metals have also been used since long for the purpose of indirect restoration especially in areas where direct restoration can’t be used [2]. Metals like titanium and its derivatives or other such alloys have been used since very long for the fabrication of dental implants and using implants in edentulous areas of the alveolar ridge or other facial bones. Implants have been also used for the purpose of orthodontic correction like mini implants [3]. The excellent Osseo integration such metals and their alloys or their modifications do make it more favorable for the purpose when comparing them with other metals which are not such “bio-suitable”. Many biomaterials have been also implied for the purpose of endodontic sealing material or as membranes in the function of periodontal healing purpose [4]. The concept of adsorption process is an area of interest when it comes to the topic of biomaterials because it is the key subject to be known when a biomaterial reacts with the body environment .6 Surface energy and charge are affected by the texture of the material used to make the biomaterial. These biomaterials are dynamically being used in the clinical field as vehicles of drug movement or as tissue replacements [5]. When a biomaterial is introduced into a living cell environment, series of events take place like adsorption of the material into the material’s surface [6,7]. The surface charge and the surface tension of the biomaterial mainly determines this interaction. An increase in surface energy improves the wettability of the material enhancing the procedure of adsorption. Surface energy and charge depend on the texture of material of which the biomaterial is made [8-13].Oxide molecules are commonly present on metals and mineralized materials commonly contributing to the negative charge which their surface offers. Surfaces which are rough at micro level offer enhanced cellular attachment and surface energy henceforth improving wettability [14]. JM Bourget, et al. focused on the normal use of bone marrow and umbilical chord blood derived Mesenchymal Stem Cells (MSCs) for vein surgeries.1 “Ortega-Oller” et al. showed the use of poly (lactic-co-glycolic destructive) (PLGA) Nano - or possibly micro particles as a movement framework for the bone morphogenetic protein (BMP) in the subject of planning bone architecture or its shape and size or in case of modification of bone size and shape as in the case of various surgical procedures which involve bone modification procedures to achieve the desired outcome of the surgical procedure. Ramos-Ziga, et al.[1] zeroed in on the regular chitosan's properties1 and its application in tissue designing, seeing it as a normal bioactive polymer for regenerative drug. “F.Piraino and Selimovi” presented courses in tissue planning and regenerative prescription to address stages portraying the human response to tissue injury by using valuable biomaterials [15]. They in like manner investigated subnuclear medications, with an extraordinary focus on drug movement development and quality meds [16]. “Fukuda et al.” made two kinds of mannose-modified lipids. Their instrument of movement to macrophages could overcome the challenges of value treatment and be used to treat immunological issues including macrophages [17-19]. Finally, “S. Abdolrahimzadeh” et al. analyzed the feasibility of several intravitreal implantations of upheld conveyance dexamethasone install in patients with decided macular edema following essential phacoemulsification inside the class of supplements. Loss of tissue in the maxillofacial region is normal because of ailment, injury, and development peculiarities. That misfortune has significant physical and psychosocial impacts for people and their families. The reconstructive specialist's goal is to return this area to an appealing and utilitarian state [20]. Destruction of tissue because of injury, sickness, and inherited reasons needs the substitution of shape and capability, driving production of tissue designing and regenerative medicine [21]. These advances are empowering in light of the fact that they get already unimaginable accomplishments skin, nerves, muscles, and concentrated tissue designing reachable. Current biomaterial innovation progresses are bringing about the production of biomaterials fit for invigorating natural response [22], Normal polymers were the first biodegradable biomaterials utilized in human restorative settings. Due to their biocompatibility, these biomaterials have better natural contact with cells, permitting them to work all the more productively in Biosystems [23] Proteins like collagen, fibrinogen, actin and so forth and polysaccharides like cellulose, chitin and so on are instances of polymers (DNA and RNA). Since ECM parts explicitly control mesenchymal undeveloped cell attachment, motility, osteogenic separation, it is normally profitable for platforms to mimic the local ECM. “Cellularized ECM created from cells is one more intriguing way for acquiring ECM like biomaterial [24]. On introduction of any biomaterial into body, progression of activities starts, starting with biomaterial adsorption to the material's surface. the surface charge and surface energy of a not entirely settled by its underlying contact with the in vivo climate. This early wetness (streak spread) coupled by biomolecule adsorption is of great importance for the microcellular environment to habitat the material to cause tissue contact with the biomaterial.

New Frontiers in Biomaterials

Chitosan is a biomaterial getting high consideration in biomaterial research. It is created by chitin basic deacetylation [25]. It is one of the most pervasive regular polymers. Chitosan has been exhibited to work on injury recuperating and bone development, as well as to repress microbes. Chitosan has antibacterial properties against Candida albicans, Enterobacter cloacae, Klebsiella pneumonia, Staphylococcus aureus, and Streptococcus pyogenes. This include is significant since it has been exhibited that antimicrobial medicines, like swathing materials and dressings, normally produce cytotoxicity, postponing recuperating or adding to microorganism obstruction. In instances of chitosan, there is a compelling reason need to utilize an added substance dressing on the grounds that the antimicrobial impacts come straightforwardly from the layer [26]. The ubiquity of chitosan for the fixing and recovery of tissues originates from the simplicity of its products in various structures like strands, wipes, and hydrogels [27]. Cold plasmas could kill microorganisms by harming the DNA and surface designs while not hurting to human tissues and cells. Cold plasma has been displayed to annihilate microbes shaping inside biofilms on teeth and in wounds. The joined activities of dressing and plasma give premise to ordinary recuperation [28]. The chitosan/ACP film is permeable, permitting gas exchange alongside Tran’s exudates of wound. Following a few days, the chitosan will disintegrate and the mending occurs.” “This application dispenses with the requirement for stitches [29]. This application also dispenses with the requirement for staples. ‘Cold plasma skin joins’ bring down the expense of medical clinic costs and lessen diseases by improving giver site recuperating. Other materials, such as third Generation bioactive glass and permeable froths, have been made determined to actuate qualities that can speed up the recovery of living tissues [30]. The utilization of Nano stage biomaterials is a better approach to making practical tissue substitutions. These materials have nanometer sized grains and show incredible osteoclast bond, bone redesigning, higher osteoblast expansion, and finally lead to formation of new bone. Nano-stage biomaterials offer surface and mechanical characteristics that are similar to bone, making them ideal for bone tissue design. The utilization of nanoparticles for outer muscle tissue recuperating is a biomimetic strategy that imitates the normal tissue's Nano layered design. These materials make a microenvironment that urges attacking cells to separate and become neotissue.

Advances of Biomaterials in Prosthodontics

Great new advancements in the subject of biomaterials have also been introduced in the field of prosthodontics. Some of them are listed below

Titanium.

Titanium alloys.

Yttria-stabilized zirconia (YTZP).

Zirconium-reinforced lithium silicate.

Lithium-Disilicate- reinforced glass ceramics.

Acrylic Resins with Enhanced Mechanical

Properties

Multi colored monolithic ceramic materials are a topic of research in recent times. These materials are used in cases where strength and aesthetics are a prime consideration. Another area that requires attention is the use of nanoparticles as reinforcements in conventional glass ionomer cement.31 A previous study found that adding 8% titanium reinforcement to glass ionomer cement reduces wear rate from nearly 35 to 25%. However, the surface hardness was not improved. The environment, mixing time, and resin proportion are all factors that can affect the mechanical properties of materials. One minor disadvantage of titanium alloy as an oral implant material is its low wear resistance. To address this issue, nanostructured ceramic coatings such as TiN, ZrO2/SiO2, Si3N4/TiO2, and ZrO2/Al2O3 are currently being used. A bilayered coating demonstrated a 200- and 500-fold increase in wear resistance over monolayer Al2O3-13TiO2 and ZrO2, respectively, due to its improved adhesion power and lower porosity. New coating layers should be created and tested in clinical settings. Researchers used various methods to create metal surface Nano-crystallization in order to improve a metal's biological activity. Chemical etching technology was used to create a Nano textured titanium surface. the effects of a Nano textured Ti surface on the proliferation; adherence, differentiation, and mineralization of murine preosteoblastic cells have previously been studied. As a result, nanophase metals appear to have great potential in both prosthetics and implantation, but more research is needed. According to research; nacre powder (the innermost layer of mollusk shells) promotes periimplant osteogenesis in domestic pig tibias. A histological study and micro-CT analysis revealed that this bioactive material promotes adequate bone formation around an implant surface. As an alternative method to promote Osseo integration, nacre powder application in conjunction with surgical implant placement can be used. Dentin matrix protein promotes human stem cell differentiation and mineralized matrix formation while also stimulating adhesion and proliferation. To improve Osseo integration in Ti implants, a biologically modified Ti surface with dentine matrix protein is recommended.

Essentialities a Biomaterial Should Posess

Biocompatible.

Biocompatible degradation products.

Noncytotoxic.

Noncytotoxic degradation products.

Noncarcinogenic.

Noncariogenic.

Nonirritant.

Nontraumatic.

Easily usable.

Easily available.

Feasible.

Easily sterlizable.

Easily predictable physical properties.

Easily predictable mechanical properties.

Easily manipulatable.

Histoconductivity.

Histoinductivity.

Specific Biomaterial Applications

Bone Regeneration and engineering.

Regeneration and engineering of Skin.

Regeneration and engineering of Mucosa.

Regeneration and engineering of Soft Tissue.

Engineering Neural Tissue.

Engineering Muscular Tissue.

Regeneration of Complex Oral tissues.

Regenerating of Mandibular condyles and mandible.

Regenerating tongue and lingual mucosa.

Biomaterials and Tissue Engineering Future

Long-term efforts of allied disciplines have been focused on finding the best way to heal a bone lesion.10 The gold standard for bone grafts is the conventional autologous procedure. However, their use is constrained and is susceptible to secondary bone resorption due to a lack of supplies and donor problems (such as chronic discomfort and hypofunction). Allograft and xenograft are now often employed in clinical settings. To reduce the induction of severe immunological rejection of the host, allogenic bone is frequently treated with freezing, freeze-drying, decalcification, or other chemical treatments, and its cell components are essentially necrotic. As a result, there are some differences in osteogenesis, manifestation during the healing process, and immunological response between allogeneic and autograft. A bone-graft substitute should be osteoconductive, osteoinductive, biocompatible, bioresorbable, physically comparable to bone, simple to use, and affordable. Furthermore, it can form an early interface for bone bonding with bone tissue, degrade over time, and eventually be completely replaced by autologous bone tissue. Current advancements in tissue design and biomaterials will enable further developed tissue developments, resulting in higher overall success rates in regenerative medication-based reconstructive medical procedure. Grown-up foundational microorganism use is appealing because it avoids the potential moral and political ramifications of using undeveloped undifferentiated cells. Advances will almost certainly include the blending of skin tissue builds with deep delicate tissue builds like subcutaneous tissue and belt. The making of a zonal ligament tissue build will be basic in the improvement of future tissue designed ligament substitutions. Progresses in bone tissue designing will in all likelihood bring about tissue developments made of bio-polymers combined with bio-active glasses or even ceramics. This probably or definitely will bring about an item with load capacities and break durability equivalent to veritable bone. The utilization of development elements and cytokines in bone tissue developments is anticipated to extend to speed up break recuperating and recovery. More refined advancements will be expected from here on out. The future fruitful advancement of Nano biomaterials may prompt the up and coming age of outer muscle substitution materials, which will be reasonable to the biomedical gadget area and can further develop generally speaking medical services. Nanoparticle applications have become valuable tools in endodontics, periodontics, restorative dentistry, orthodontics, and oral cancer treatment. Because of their antimicrobial properties, silver nanoparticles (AgNPs) have been used in medicine and dentistry. AgNPs have been incorporated into biomaterials to prevent or reduce the formation of biofilms. They have excellent antimicrobial action without affecting the mechanical properties of the material due to their higher surface to volume ratio and small particle size, because of this unique property, AgNPs are popular fillers in various biomaterials, where they play an important role in improving the properties. The purpose of this review is to discuss the impact of adding AgNPs to various biomaterials used in various dental applications. More in-depth knowledge of the complexities of growth factor treatment and hereditary designing may aid in the development of better strategies to repair working fringe nerve tissue.

References

1. Selimovic S, Piraino F, Gauvin R, et al. New biomaterials in drug delivery and wound care. Biomed Res Int 2015.

Indexed at, Google Scholar, Cross Ref

2. Heboyan A, Zafar MS, Rokaya D, et al. Insights and advancements in biomaterials for prosthodontics and implant dentistry. Molecules 2022; 27:5116.

Indexed at, Google Scholar, Cross Ref

3. Luong D, Kesharwani P, Deshmukh R, et al. PEGylated PAMAM dendrimers: Enhancing efficacy and mitigating toxicity for effective anticancer drug and gene delivery. Acta Biomater 2016; 43:14-29.

Indexed at, Google Scholar, Cross Ref

4. Ferracane JL, Giannobile WV. Novel biomaterials and technologies for the dental, oral, and craniofacial structures. J Dent Res 2014; 93:1185.

Indexed at, Google Scholar, Cross Ref

5. Zhang Q, Wu W, Qian C, et al. Advanced biomaterials for repairing and reconstruction of mandibular defects. Mater Sci Eng C 2019; 103:109858.

Indexed at, Google Scholar, Cross Ref

6. Triplett RG, Budinskaya O. New frontiers in biomaterials. Oral Maxillofac Surg Clin 2017; 29:105-15.

Indexed at, Google Scholar, Cross Ref

7. Melek LN. Tissue engineering in oral and maxillofacial reconstruction. Tanta Dent J 2015; 12:211–23.

Indexed at, Google Scholar, Cross Ref

8. Atala A, Lanza R, Mikos T, et al. Principles of regenerative medicine. Academic press 2018.

Google Scholar

9. Anderson JM. The future of biomedical materials. J Mater Sci Mater Med 2006; 17:1025–1028.

Indexed at, Google Scholar, Cross Ref

10. Abou Neel EA, Chrzanowski W, Salih VM, et al. Tissue engineering in dentistry. J Dent 2014; 42:915-928.

Indexed at, Google Scholar, Cross Ref

11. Boyan BD, Batzer R, Kieswetter K, et al. Titanium surface roughness alters responsiveness of MG63 osteoblast-like cells to 1 alpha,25-(OH)2D3. J Biomed Mater Res 1998; 39:77–85.

Indexed at, Google Scholar, Cross Ref

12. Kieswetter K, Schwartz Z, Hummert TW, et al. Surface roughness modulates the local production of growth factors and cytokines by osteoblast-like MG-63 cells. J Biomed Mater Res 1996; 32:55–63.

Indexed at, Google Scholar, Cross Ref

13. Loh QL, Choong C. Three-dimensional scaffolds for tissue engineering applications: Role of porosity and pore size. Tissue Eng Part B Rev 2013; 19:485–502.

Indexed at, Google Scholar, Cross Ref

14. Melek LN. Tissue engineering in oral and maxillofacial reconstruction. Tanta Dental J 2015; 12:211–223.

Indexed at, Google Scholar, Cross Ref

15. Gomes ME, Ribeiro AS, Malafaya PB, et al. A new approach based on injection moulding to produce biodegradable starch-based polymeric scaffolds: morphology, mechanical and degradation behaviour. Biomaterials 2001; 22:883–889.

Indexed at, Google Scholar, Cross Ref

16. Hottot A, Vessot S, Andrieu J. Determination of mass and heat transfer parameters during freeze-drying cycles of pharmaceutical products. PDA J Pharm Sci Technol 2005; 59:138–153.

Indexed at, Google Scholar

17. Wu GH, Hsu S. Review: Polymeric-based 3D printing for tissue engineering. J Med Biol Eng 2015; 35:285–292.

Indexed at, Google Scholar, Cross Ref

18. Jia H, Zhu G, Vugrinovich B, et al. Enzyme-carrying polymeric nanofibers prepared via electrospinning for use as unique biocatalysts. Biotechnol Prog 2002; 18:1027–1032.

Indexed at, Google Scholar, Cross Ref

19. Amini AR, Laurencin CT, Nukavarapu SP. Bone tissue engineering: Recent advances and challenges. Crit Rev Biomed Eng 2012; 40:363–408.

Indexed at, Google Scholar, Cross Ref

20. Hasan A, Paul A, Vrana NE, et al. Microfluidic techniques for development of 3D vascularized tissue. Biomaterials 2014; 35:7308–7325.

Indexed at, Google Scholar, Cross Ref

21. Jakab K, Norotte C, Marga F, et al. Tissue engineering by self-assembly and bio-printing of living cells. Biofabrication 2010; 2:022001.

Indexed at, Google Scholar, Cross Ref

22. Peck M, Gebhart D, Dusserre N, et al. The evolution of vascular tissue engineering and current state of the art. Cells Tissues Organs 2012; 195:144–158.

Indexed at, Google Scholar, Cross Ref

23. Groschel AH, Walther A, Lobling TI, et al. Guided hierarchical co-assembly of soft patchy nanoparticles. Nature 2013; 503:247–251.

Indexed at, Google Scholar, Cross Ref

24. Budinskaya OV, Kontogiorgos ED, Brownlee M, et al. Vacuum-induced suction stimulates increased numbers of blood vessels in healthy dog gingiva. Wounds 2012; 24:99–109.

Indexed at, Google Scholar

25. Akman AC, Seda Tıglı R, Gumusderelioglu M, et al. Bone morphogenetic protein‐6‐loaded chitosan scaffolds enhance the osteoblastic characteristics of MC3T3‐E1 cells. Artif Organs 2010; 34:65-74.

Indexed at, Google Scholar, Cross Ref

26. Rodriguez-Vazquez M, Vega-Ruiz B, Ramos-Zuniga R, et al. Chitosan and its potential use as a scaffold for tissue engineering in regenerative medicine. BioMed Res Int 2015.

Indexed at, Google Scholar, Cross Ref

27. Wu HD, Ji DY, Chang WJ, et al. Chitosan-based polyelectrolyte complex scaffolds with antibacterial properties for treating dental bone defects. Mater Sci Eng C 2012; 32:207–214.

Indexed at, Google Scholar, Cross Ref

28. Ermolaeva SA, Varfolomeev AF, Chernukha MY, et al. Bactericidal effects of non-thermal argon plasma in vitro, in biofilms and in the animal model of infected wounds. J Med Microbiol 2011; 60:75–83.

Indexed at, Google Scholar, Cross Ref

29. Ziuzina D, Patil S, Cullen P, et al. Atmospheric cold plasma inactivation of Escherichia coli in liquid media inside a sealed package. J Appl Microbiol 2013; 114:778–87

Indexed at, Google Scholar, Cross Ref

30. Ziuzina D, Boehm D, Patil S, et al. Cold plasma inactivation of bacterial biofilms and reduction of quorum sensing regulated virulence factors. PLoS One 2015; 10:e0138209.

Indexed at, Google Scholar, Cross Ref