Screening the anticancer activity, cytotoxicity and anti-osteoarthritic activity of Drynaria quercifolia through Saos2 cell line studies
Author(s): Lakshman RR, Vasanth S, Bupesh G*, Balachandar V and Saravanan KM
Abstract
In the present work, we investigated cytotoxicity activity against SAOS2 cell lines, Drynaria quercifolia, a medicinal plant having the elements of a Southern India recipe for cancer therapy, was chosen. The MTT assay was performed to determine the cell type's cytotoxic activity. After testing several concentrations in three different plant extracts, such as methanol, ethanol and aqueous extracts against cell lines, the active plant extracts were diluted and tested for calculating IC50. Plant extracts (D. quercifolia) demonstrated specific activity against cancer and osteoarthritic cell lines as compared to normal cells and should be explored further for active chemicals.