Prognostic Relevance of Serum Ferritin on Short Term and Long term Outcome In Patients With Acute Myocardial Infarction
Author(s): Subhasish Singh, Rashmita Pradhan*, Nipa Singh
Abstract
Background and Objective: Over the decades coronary artery disease appears to be an emerging cause of mortality and morbidity. Previous studies suggested elevated serum ferritin as a risk factor for development of AMI. However its role with regard to outcome and prognosis of AMI still remains a matter of debate. With this background, the present study was aimed to estimate the prognostic relevance of serum ferritin in relation to short term and long term survival outcomes in patients with AMI. Methods: The study was a hospital based observational study conducted with a total number of 100 patients, with first AMI (50 suffered STEMI and 50 with NSTEMI diagnosis) admitted within 12 hours of the onset of chest pain to coronary care units (CCU) at MKCG Medical College & hospital over a period of one year. Serum ferritin was measured using an ELISA assay by a special kit. The patients were divided into three groups according to Serum ferritin level. i.e. (1st tertile: <120 ng/ml, 2nd tertile: 120 to 220 ng/ml and 3rd tertile: >220 ng/ml). Baseline characteristics, LV Ejection Fraction, Killip functional class and outcomes were compared among three different groups of serum ferritin. Results: There was a significant correlation between serum ferritin and LV ejection fraction (p=0.01), Killip class (p=0.03) and mortality (p=0.03). Lower and higher levels of ferritin (1st and 3rd tertiles, ≤ 120; >220 ng/ml, respectively) were associated with a higher incidence of HF during hospitalization and death at 1 year. Conclusion: Raised serum ferritin is associated with worse short term and long term outcome following myocardial infarction.