Preparation and Anti-Inflammatory Activity of Mouthwash Prepared Using Red Sandal Mediated Selenium Nanoparticles
Author(s): Obuli Ganesh Kishore S, Lakshminarayanan Arivarasu* and Rajesh Kumar S
Abstract
Introduction: Application of herbal medicine has been advancing rapidly. Red sandalwood is one such plant with medicinal properties. The wood is used as an astringent and tonic for external application in inflammation. Metal nanoparticles have a special place in the area of nanotechnology as they offer a unique opportunity not only as theranostic agents but possess tremendous potential as carriers for chemotherapeutic agents, proteins etc. One application of nanotechnology in medicine currently being developed involves employing nanoparticles to deliver drugs, heat, light or other substances to specific types of cells.
Aim: The objective of this study is to assess the anti-inflammatory activity of mouthwash prepared from red sandalwood mediated selenium nanoparticles.
Materials and methods: The plant extract was first prepared and the selenium nanoparticles were added and mixed well. To prepare mouthwash, measured quantities of sucrose, sodium Benzoate, SLS, peppermint oil, distilled water and the prepared extract were added and mixed. To assess the anti-inflammatory activity albumin denaturation assay was performed.
Results: From the above study conducted it is evident that keeping diclofenac sodium as the control, and its absorbance value to be 0.172, the absorbance value of the prepared mouthwash from the extract was recorded in different concentrations. After reaching the concentration of 30, 40 and 50 microliters the prepared extract began to show considerably close absorbance values compared to the standard. At 50 microliters concentration the absorbance value of the mouthwash was found to be higher than that of the standard.
Conclusion: From the above study we can conclude that the mouthwash prepared from the extract can be used as a good anti-inflammatory agent. The limitations of the study are less sample numbers, comparison with single standards etc. Furthermore developments in this field may lead to production of herbal anti-inflammatory mouthwash.