Oxidative Stress in Gestational Diabetes
Author(s): B Jaya*
Abstract
In this the present study the serum levels of oxidant¬ Malondialdehyde and antioxidant- Ceruloplasmin are compared between the different trimesters of pregnancy in both groups - The mean serum MDA levels in the total study group are l .64nmol/ml in the first trimester. The mean serum MDA level of group1 is l .63nmol/ml and of group II is 1.71 nmol/ml showing that there is no significant difference between the groups in the first trimester. In the second trimester the mean MDA levels in the uncomplicated antenatal subjects (group 1) increased to 2.89nmol/ml compared to the first trimester levels with a p value <0.05 which IS significant. In the second trimester the mean serum level of MDA 1n the GDM (group 2) subjects are 4.17nmol/ml which 1s significantly increased compared to their first trimester level with a p value< 0.01). Comparison of group 1 and group 2 MDA levels shows a p value <0.05 which is statistically significant increase in group 2 subjects. This may be due to increased oxidative stress prevalent in GDM causing an increase in oxidant MDA levels. In the third trimester, the was also similar result and an insignificant decrease 1n mean Cp levels in GDM subjects when compared to uncomplicated pregnant subjects in the second trimester. The results also shows .There is no significant association between MDA and Cp in the three trimesters of group I subjects.
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