Evaluation of efficacy of L-PRF with and without hyaluronic acid on pain, soft tissue healing and swelling post surgical transalveolar extraction of mandibular molars: A comparative study
Author(s): Tanvi Tiwarekar*
Abstract
Tooth extraction, a common dental procedure addressing decay, fractures, periodontal disease, infections, and orthodontic needs, initiates a natural healing process in the post-extraction socket involving bone cell migration and selective bone resorption and apposition. However, this process often leads to dimensional loss in the alveolar ridge, complicating tooth replacement, especially in implant therapy. Preventive measures like socket preservation with grafts and immediate or early implant placements are employed to mitigate post-extraction bone loss. Socket preservation aims to minimize dimensional changes in the alveolar ridge, while immediate implant placements, though advantageous, can sometimes cause buccal bone defects, necessitating grafts with lower success rates. LeukocytePlatelet Rich Fibrin (L-PRF), a significant advancement in regenerative medicine, is derived from the patient's blood through controlled centrifugation, creating a fibrin matrix enriched with platelets, leukocytes, and growth factors. L-PRF's autologous healing properties have broad applications in dentistry, orthopedics, dermatology, and beyond. In dentistry, it enhances bone grafting, implantology, and periodontal surgery by promoting tissue regeneration and infection control. As an autologous therapy, L-PRF reduces the risk of immune reactions or disease transmission, offering a safe and effective regenerative solution. Hyaluronic Acid (HA), a naturally occurring glycosaminoglycan in the human body, is essential for skin hydration, joint lubrication, and tissue integrity. HA's ability to attract and retain water molecules makes it a key component in skincare for reducing fine lines and promoting a youthful complexion. In the medical field, HA is used in joint injections to alleviate osteoarthritis symptoms due to its biocompatibility and non-immunogenic properties. This study aims to evaluate the effectiveness of autologous Platelet-Rich Fibrin (PRF) membranes in enhancing post-extraction socket healing. Derived from non-anticoagulated blood, PRF is proposed to accelerate wound healing, increase bone fill, and reduce bone resorption. The research explores the broader applications of L-PRF and HA, highlighting their roles in advancing regenerative medicine and aesthetics. The intersection of these innovative approaches addresses immediate dental concerns and paves the way for broader medical applications, underscoring continuous advancements in medical science.