Evaluation of Anti-Hyperlipidemic Activity of Clerodendrum Serratum on High Cholesterol Diet Induced Hyperlipidaemia in Rats
Author(s): K Mahammad Areef*
Abstract
Obesity has turned up as one of the major health concerns in the 21st century and is one of the leading causes of preventable death. Obesity is a term applied to excess body weight with an abnormally high proportion of body fat. Thermo dynamically speaking, imbalance between energy intake (feeding) and energy expenditure. Development of obesity is, however, more complicated than that; sedentary life style, genetic factors, medical illness, microbiological aspects, social factors and neurobiological mechanisms are also involved. Pre-clinical evaluator study of compound can be done by using three animal models i.e., drug induced obesity, food induced obesity and genetically modified C57BL/6J female mice. The neuro active steroid, progesterone is a female reproductive hormone. Its level increases during the later phase of the menstrual cycle and controls the secretory phase of the endometrium. Substantial evidence links progesterone excess in pathophysiology of eating and affective disorders. Some reports suggest the use of progesterone containing preparations as contraceptive or for the hormone replacement therapy to cause sufficient weight gain by causing hyperphagia and increased fat deposition in the body.