Effectiveness of Hyaluronic Acid Local Application in the Socket after Surgical Extraction of Impacted Lower Third Molars. A Prospective Randomized Controlled Clinical Study
Author(s): Kadhim Hussain Jalal* and Auday M. Al-Anee
Abstract
Background: Hyaluronic Acid (HA) has been investigated for a long time in various applications. It has been found practically in multiple tissues in humans and other animals. HA is a versatile material. These unusual physicochemical features have been used for various medical objectives.
Aims: Evaluate effectiveness of the local application of Hyaluronic Acid (HA) gel in reducing pain and edema after impacted mandibular third molars removal.
Materials and methods: Fifty patients who met the inclusion criteria whose mean age (25.28) years were randomly allocated to one of two groups. Patients in Group I (study group) had hyaluronic acid gel inserted in the socket after surgical removal of the mandibular third molar (N=25). Group II (control group) had no H.A. put in the socket after surgical removal of the mandibular third molar (N=25). Pernambucco index was used as difficulty scoring to evaluate the cases, decrease bias of results and to give fact results. Type of impaction in our study (62% vertical and 38% mesioangular). Preoperative measurements and postoperative measurements (1st, 3rd and 7th days) for swelling was taken using (Gabka and Matsumara method), and postoperative pain (1st, 3rd and 7th days) was recorded subjectively by (visual analogue scale). The statistical analysis of results was done using the Mann-Whitney U test.
Results: Fifty patients (39 female and 11 male) contributed to this study. No Significant difference has been found between the two groups in pain and facial swelling at different days of assessment during the study (day 1, day 3 and day 7) (p>0.05).
Conclusion: Hyaluronic acid gel decreases pain clinically but is non-significant statistically and has no effect on facial swelling after surgical extraction of impacted lower third molars.