Correlation of Irisin with the Inflammatory Parameters and Liver Function in Rheumatoid Arthritis Patients.
Author(s): Zainab Qasim Muhammad Al-Yasiri* and Khalid Gatee Al-Fartosi
Abstract
This study was designed with the aim of investigating the relationship of irisin with some biochemical and inflammatory parameters, among patients with rheumatoid arthritis in Thi Qar Governorate/Iraq. The study included 100 women with rheumatoid arthritis diagnosed by a specialist doctor, their ages ranged between 30-80 years. With 50 healthy women of the same age representing a control group, Blood samples were used for examine the Erythrocyte Sedimentation Rate (ESR), and serum which used to measure Rheumatoid Factor (RF), Anti-Cyclic Citrullinated Peptides (ACCP), irisin, Also, a liver function test, as well as inflammatory Parameters. The results of our study showed a significant decrease (p≤0.05) in the level of irisin in patients compared to the control group. On other hand, the second age group (GII≥50 years) of patients showed a significant decrease (p≤ 0.05) in the concentration of irisin compared to the first age group (GI<50 years). Also the results recorded a significant increase (p≤ 0.05) in the levels of RF and ACCP in the patients compared to the control group. While, we note that there is no significant difference (P>0.05) in the concentration of RF and ACCP for patients when comparing the age groups. In contrast, If we look at the liver function test, we notice that there is a significant increase (p≤0.05) in the concentration of ALP and GPT, while there was no significant difference (P>0.05) in the concentration of GOT in the patients compared to the control group. While, based on the age group, the results showed that, ALP concentration was significantly increased (p≤0.05) in the second group of patients (GII≥50 years) compared to the first group (GI<50 years). In contrast, no significant differences (P>0.05) are observed in the GPT and GOT concentration when comparing the two groups of patients with each other. On the other hand, when we talk about the inflammatory parameters under study, we find that, IL-6, CRP and ESR, were significantly increased (p≤0.05) in patients compared to the control group. In addition to, when comparing patients, based on age groups, we find that ESR value, has significantly increased (p≤0.05) in the second age group of patients (GII≥50 years) compared to the first group (GI<50 years), while, the rest of the inflammatory parameters did not show any Significant differences (P>0.05). Finally, Correlation analysis of the results obtained from the current study on patients with rheumatoid arthritis indicated a negative correlation between irisin with RF, ACCP, GPT, GOT, ALP, IL-6, CRP and ESR..