Co-relation of Acanthosis Nigricans with Insulin Resistance and Type 2 Diabetes Mellitus in a Tertiary Care Hospital
Author(s): Rakhshinda Jabeen*, Tazeen Rasheed and Humera Talat
Abstract
Objective: To adjudicate the correlation of Acanthosis Nigricans (AN) with Insulin Resistance (IR) and type 2 diabetes mellitus in a tertiary care hospital.
Methodology: This case control study was administered at Dr. Ruth K. M. Pfau, civil hospital, Karachi between 1st October 2019 to 31st March 2020. A total of 308 patients were enrolled in this study. The patients were disintegrate into two groups, first group having AN of any degree with a BMI of ≥ 25 kg/m2, and they were compared with the control group without AN but having same BMI of ≥ 25 kg/m2. HbA1c and HOMA-IR were calculated for each patient.
Results: Out of 308 patients involved in the study, 204 (66.23%) were females while 104 (33.77%) were males. Mean age among male patients was 38.39 ± 8.70 years whereas that of female patients was 35.49 ± 9.41 years. While comparing IR with AN in both groups, it was statistically eloquent with p value of 0.000. Diabetes mellitus was seen in 34.6% in AN positive patient while 41.3% without AN had type 2 DM.
Conclusion: IR increases with increasing BMI irrespective of presence or absence of AN. DM is also significantly associated with obesity irrespective of presence or absence of AN.