Assessment the Levels of Leptin, Adiponectin, and Insulin Resistance in Iraqi Women with Polycystic Ovary Syndrome (PCOS)
Author(s): Afrah N Faris*, Khalid G Al-Fartosi and Wassan R Al-Khafaji
Abstract
The objectives of this paper is to investigate the leptin and adiponectin levels in women with polycystic ovary syndrome (PCOS)., as well as their relationship to insulin resistance. A case-control study was conducted in private health institutions in Thi-Qar Governorate, iraq from March 1, 2021 to September 30, 2021, and included 100 married women with PCOS and infertility and 80 healthy married couples, who diagnosed by gynecologists. Venous blood was sampled from fasting participants for the determination of parameters of this study. The results showed a significant elevation in the levels of BMI, leptin, fasting blood sugar(FBS), insulin and HOMA-IR while there was a significant decline in the level of adeponectin in the patients with PCOS group compared to the control group regardless of body mass index (p<0.05). According to the study's findings, leptin and adiponectin levels might be considered useful indicators in the early diagnosis of PCOS, as well as treatment targets, it appears to be a positive relationship between insulin resistance and leptin and a negative relationship with adiponectin in PCOS patients.