Analyzing Glycyrrhiza Glabra (Licorice) Extract Efficacy in Recurrent Aphthous Stomatitis Recovery
Author(s): Salehi M, Saeedi M, Ehsani H, Sharifian A, Moosazadeh M, Rostamkalaei S, Babaei Hatkehlouei M, Molania T
Abstract
Oral aphthous is of prevalent oral ulcers occurring as the recurrent ones. Various factors influence oral aphthous etiology such as mental disorders, immunity, blood disorders and stress. To treat these ulcers, different methods including steroids, antibiotics, anti-inflammatory and analgesics are recommended. In the present study, the effect of a sort of buccoadhesive licorice tablet has been analyzed for aphthous stomatitis recovery. The current research is of clinical trials. The study community has been selected out of those referring to Oral and Maxillofacial Diseases Department of The Faculty of Dentistry affiliated with the University of Medical Sciences of Mazandaran in 2016.In the first stage, according to the inclusion criteria, 42 subjects have been selected by convenient sampling and in the continuation, the samples have been randomly and alternately assigned to two groups. Twenty-one (21) patients have been placed in the mucoadhesive licorice tablets intervention group and twenty-one (21) ones in non-medicine base buccoadhesive control group. Finally, the results will enter SPSS20 for analysis. Based on Chi-square test, the time of reaching analgesia and full recovery from aphthous ulcer in the intervention group is meaningfully lower than that of the control group (P<0.001). Also all the intervention group subjects have fully recovered on day 7 (P<0.001). Regarding the anti-inflammatory effects of licorice and the current study derived results, mucoadhesive licorice extract tablets has the potential to alleviate pain, reduce ulcer's diameter and its surrounding inflammation and to accelerate the aphthous stomatitis recovery time.
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